PhD Position in Biofabrication and 3D BioPrinting

Musculoskeletal injuries are widespread and can significantly impact quality of life. The field of tissue engineering and bioprinting is constantly seeking new methods to create biomimetic tissue models that better replicate the organization of native tissues. Bioprinting strategies have the potential to revolutionize the functionality of tissues used in regenerative medicine.

The Tissue Engineering and Biofabrication Laboratory (Prof. Marcy Zenobi-Wong) within the Department of Health Sciences & Technology (D-HEST) at ETH Zurich, Switzerland, uses bioprinting to produce tissues that address unmet clinical needs. The laboratory has recently developed a light-based 3D printing technique capable of creating topological cell guiding cues in large scaffolds (> centimeter scale) based on optical modulation instability and self-focusing effects on non-linear media (e.g., photosensitive resin). This allows for creating efficient cell guiding microstructures, including microfilaments and microchannels in 3D hydrogel constructs within seconds.

The goal of this project is to further enhance the printing technique by incorporating three different wavelength lasers. This new printer will be able to crosslink materials into 3D shapes using one of the wavelengths, while the other two wavelengths will be leveraged to optically stimulate the resident cells.

• Design, assembly, and validation of multiwave bioprojection system
• Establish and test software-hardware control of the system
• Optimization of light pattern and seamless multi-wavelength projection
• Optimization of safety, reliability, and heat transfer properties of the printer
• Develop applications for the multichromatic printer

You have a diploma/M.Sc. degree in mechanical engineering or biomedical engineering with strong motivation to develop the hardware and software behind the next generation of 3D bioprinters. You will work on this project together with a biology PhD student, therefore strong interest in working on interdisciplinary, biomedical research questions is essential. The following skills are sought:

• Programming: Proficiency in Python and understanding of basic software engineering (required)
• Mechatronics: Understanding of communication between devices and communication protocols such as Serial, I2C, UART, JTAG, SSH, FTP, SCP, VNC (required)
• Good knowledge of Linux operating system, especially in combination with Raspberry Pi operation and Arduino (recommended)
• Rapid prototyping (CAD and FDM printing) skills and ability to model heat dissipation, air, and fluid flow (recommended)
• Physics and Optics: Basic understanding of optics, lasers, and diffraction is useful (optional)
• Biomaterials and Chemistry: Familiarity with common bioprinting materials and chemical principles is useful but not required (optional)
• Motivation to work in a multidisciplinary and multicultural environment
• Excellent oral and written communication skills

• An open and collaborative research environment
• Access to and training in cutting-edge methodologies and instrumentation
• Possibilities to develop entrepreneurial skills and training

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity, and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

We look forward to receiving your online application with the following documents:

• A motivation letter describing how your background fits the profile, your scientific interests, and scientific achievements to date (max. 2 pages)
• CV and Transcripts from MSc and BS degrees
• Contact information of 3 references

The position is available from October 1, 2024, and must be started before March 1, 2025.

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

Further information about our laboratory can be found on our website. Questions regarding the position should be directed to Prof. Marcy Zenobi-Wong, Tel 044 632 5089 or email marcy.zenobi@hest.ethz.ch (no applications).

ETH Zurich is one of the world’s leading universities specializing in science and technology. We are renowned for our excellent education, cutting-edge fundamental research, and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.