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The Rheumatology Division at the Department of Medicine, Solna, performs translational research to understand the molecular mechanisms behind severe chronic rheumatic diseases. Our division consists of several independent groups involved in research and doctoral education, working collaboratively to enhance our understanding of rheumatic diseases. The close proximity and collaboration between our clinics and the immunology laboratory make our division unique.
Katerina Chatzidionysiou's research focuses on immune-related arthritis, a new form of chronic arthritis caused by treatment with checkpoint inhibitors, a type of immunotherapy in cancer. The research projects will be conducted in collaboration with Karine Chemin's team at the Centre for Molecular Medicine. This opportunity allows you to work in a pioneering field of rheumatology related to oncoimmunology, in one of the world's leading rheumatology/immunology labs.
Immune checkpoint inhibitors (ICI) targeting inhibitory receptors have demonstrated clinical efficacy against various cancers. However, treatment with ICI is associated with immune adverse events (ir-AEs) that can affect any tissue type. Your research will focus on ir-AEs targeting the synovial joint, leading to arthritis that often becomes chronic and requires immunosuppressive treatment. The aim is to analyze immune cell subsets and signatures in the synovial joint and blood of these patients. You will oversee and perform single-cell sequencing analysis (10X genomics) with appropriate control steps. Responsibilities include figure and manuscript preparation, electronic lab book reports, and lab presentations. You will also provide bioinformatic support for additional projects within the group. Depending on your profile, cell sorting and validation experiments may be part of your mission.
The ideal candidate should have experience in bioinformatics applied to single-cell sequencing data using R and/or Python. You should have first-author publications in peer-reviewed journals demonstrating your bioinformatic skills. Experience with single-cell dataset integration, velocity, and whole-genome sequencing analyses is a plus. You should be able to work in an interdisciplinary group, be rigorous, and have an interest in translational immunology.
To be eligible for employment as a postdoc, a doctoral degree or a foreign degree deemed equivalent to a doctoral degree is required. This requirement must be fulfilled by the time of the employment decision. It is advantageous if you have completed your doctoral degree within the last three years, though exceptions may be made for earlier completions under special circumstances.
We offer a creative and inspiring environment with a wide range of expertise and interests. Karolinska Institutet is one of the world's leading medical universities, conducting successful medical research and offering the largest range of medical education in Sweden. At KI, you will meet researchers from various specializations and methods, providing ample opportunities for knowledge exchange and collaboration across medical and health sciences. Our close relationship with healthcare providers is crucial for creating groundbreaking education and research. As a state university, we offer several benefits through our collective agreement.
The position is located within the Department of Medicine, Solna. The department consists of eleven divisions, each with several research groups. You will be part of Katerina Chatzidionysiou's research group (https://ki.se/en/people/aikaterini-chatzidionysiou) and collaborate with Karine Chemin's team at CMM (https://ki.se/en/people/karine-chemin). Katerina Chatzidionysiou is a rheumatologist and clinical researcher responsible for the clinical trial unit at Karolinska University Hospital and the cohort of patients with rheumatic ir-AEs.
An employment application must include the following documents in English or Swedish:
The application is to be submitted through the Varbi recruitment system.
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Contact: Katerina Chatzidionysiou, 0762119018
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